I had this done several years ago, when I lived in Winter Park. They had a machine called a Vac Therapy, but the machine is no longer being sold, as I can't find it online. I remember it did kind of hurt, but afterwards the blood flow to the areas felt so good. I did it for back pain because of blood stasis at the time, but they also used the machine for cellulite treatments.
However, one can find the Bellabaci Cups online and also at Amazon.com.
Sunday, August 19, 2012
Friday, August 17, 2012
The Orginal Bug Gun & Mosquito Solution
One thing I can't stand is going outside and being molested by all the flying troll insects.
What's even worse is when they get into your home.
There's a gun that will zap them. Yep, there really is a Bug Gun.
Check it out...
Martin Paul 100-75 Flyshooter The Original Bug Gun, Colors may vary
Take that you pesky trolls!
And this....
An itch-free summer is now possible without bug spray!
“New research has shown mosquito bites can be prevented by encouraging the body to create mosquito-repelling compounds. Chemicals created by the skin cause mosquitoes to fly away instead of biting. Two Hawaii-based natural healers (staff at our former health retreat) have developed a product… that keeps mosquitoes from biting by confusing their sense of smell.
Putting substances on the body or in the air is a common way to repel mosquitoes with scents they identify as unpleasant. (I personally find they make me nauseous and I refuse to put harmful chemicals on my skin.) Home remedies to keep bugs away have long included foods like lemon thyme, catnip in the form of oil, garlic, and vitamins, like B1. Mixed results have been reported.
…By supporting the immune system and encouraging the skin to produce its own repellent, mosquitoes aren’t attracted anymore. They get confused, and instead of biting, they look elsewhere for a meal.
Mosquito Solution is an all-natural product with simple, non-toxic ingredients suitable for all ages. To stop bites for 3 hours, take 2 dropperfuls of Mosquito Solution, swish in the mouth for 30 seconds and swallow. That’s it.”
For more info CLICK HERE: Mosquito Solution or contact: Anita 808-937-2556
Anita tells me it works for 8 out of 10 people. They offer a money-back guarantee for the unlucky 2.
What's even worse is when they get into your home.
There's a gun that will zap them. Yep, there really is a Bug Gun.
Check it out...
It actually works! The Flyshooter is handy to have at home, office, picnics, boating, camping, hunting, fishing, anywhere and everywhere. The "gun's" projectile is constructed like a flyswatter and smashes bugs against flat objects when fired correctly within the Flyshooter's range. A fun way to knock out annoying bugs taking some fun out of your experience. Assorted colors (sorry, no choice). Made in USA.
Martin Paul 100-75 Flyshooter The Original Bug Gun, Colors may vary
Take that you pesky trolls!
And this....
An itch-free summer is now possible without bug spray!
“New research has shown mosquito bites can be prevented by encouraging the body to create mosquito-repelling compounds. Chemicals created by the skin cause mosquitoes to fly away instead of biting. Two Hawaii-based natural healers (staff at our former health retreat) have developed a product… that keeps mosquitoes from biting by confusing their sense of smell.
Putting substances on the body or in the air is a common way to repel mosquitoes with scents they identify as unpleasant. (I personally find they make me nauseous and I refuse to put harmful chemicals on my skin.) Home remedies to keep bugs away have long included foods like lemon thyme, catnip in the form of oil, garlic, and vitamins, like B1. Mixed results have been reported.
…By supporting the immune system and encouraging the skin to produce its own repellent, mosquitoes aren’t attracted anymore. They get confused, and instead of biting, they look elsewhere for a meal.
Mosquito Solution is an all-natural product with simple, non-toxic ingredients suitable for all ages. To stop bites for 3 hours, take 2 dropperfuls of Mosquito Solution, swish in the mouth for 30 seconds and swallow. That’s it.”
For more info CLICK HERE: Mosquito Solution or contact: Anita 808-937-2556
Anita tells me it works for 8 out of 10 people. They offer a money-back guarantee for the unlucky 2.
Tuesday, August 14, 2012
ADVERSE REACTION TO HEPATITIS B VACCINE GIVEN TO NEW BORN
Because the brain dead sheeple aren't getting it yet? Have to post this, until they do.
ADVERSE REACTION TO HEPATITIS B VACCINE GIVEN TO NEW BORN!
With no recorded cases of hepatitis B among infants and children of commonly healthy mothers, the question MUST be asked by any clear thinking person why most states now mandate and or coerce parents into vaccinating their infants and children with a serum created largely for prostitutes and promiscuous male homosexuals?
A vaccine with the full extent of it's horrific side effects remain largely unknown because there has not been or is currently a single case of scientific medical research into the true side effects of this vaccine given to innocent new born babies, again, a vaccine designed for prostitutes and promiscuous male homosexuals!
While known rates of MS, asthma, SIDS, Cancer, Heart Disease and other afflictions have been increasing in children and have been linked to hepatitis B vaccinations, the full extent of its gross and subtle effects on injected children will never be known for many, many decades–if ever, because no science or medical research is being done ON THIS INSANE VACCINE GIVEN TO INNOCENT BABIES!!
Today millions of infants are being IGNORANTLY injected, allegedly for their own good, with a sexual prophylactic, toxic in its natural form DISEASE RIDDLED, DISEASE CAUSING VACCINES. Who are these INSANE injections designed to protect, for sure not our babies? DO YA THINK MAYBE NOW IT'S TIME TO WAKE UP??
Ian Larsen Gromowski. http://iansvoice.org/default.aspx
Remember why so many "Christians" kept a blind eye during the Holocaust... it was not happening to them.
* There seems to be nothing on the site as the content is always being taken down, or perhaps hacked.
http://www.drbloem.com/video/ian-larsen-gromowski-hepatitis-b-vaccine.htm
Baby Ian did pass away.
I know that his website keeps getting shut down, the medical community does not want people to see this. You can learn more just by googling: Baby Ian Hep B Vaccine. I found the story here. As painful as it is--I can't stop crying--I think people need to see this so they see what vaccines are doing to our children. So tragic and completely unnecessary. Wake up, stupid people!
http://www.cafemom.com/group/110860/forums/read/16415160/Baby_Ians_Struggle_with_the_HepB_Graphic_Pics
http://gaia-health.com/gaia-blog/2012-08-14/hepb-vaccine-causes-liver-disease-science-documents-shows-how/
http://www.followingvaccinations.com/
 |
| Ken O'Toole " This was the last time I was able to hold Ian. I held him for two hours. Ian fell asleep in my arms. I will hold this particular memory in my heart forever. My son looked me in the eyes and fell asleep in the comfort and warmth of my arms. Nothing could ever replace that feeling." Deanna Gromowski |
http://www.drbloem.com/video/ian-larsen-gromowski-hepatitis-b-vaccine.htm
Wise Up Journal - » Baby Ian’s brave struggle with the Hepatitis B vaccine *
The post refers to little Ian Gromowski, who was murdered with a "routine vaccination". Yes, it was murder in the 3rd degree. (Manslaughter) Nobody went to prison, while the pharmaceutical companies are defending legislation to "fast track" future poisons.
Iansvoice.org seems to be out of service, but a search for Ian's name via www.startpage.com will produce the details.
-------------------------------
Two of the Hep B vaccine package insert (prescribing information) DIRECTLY from the pHARMa companies ADMITTING that their product/s CAUSE disease. So by all means, don't take my word for it.
http://www.merck.com/product/usa/pi_circulars/c/comvax/comvax_pi.pdf
Pages 9-10
Injection Site Reactions: Pain/tenderness/soreness, swelling/induration, erythema; Body as a Whole: Fever; Digestive System: Anorexia, diarrhea, vomiting; Nervous System/Psychiatric: Irritability, somnolence, crying; Respiratory System: Upper respiratory infection, rhinorrhea, cough, rhinitis; Skin: Rash; Special Senses: Otitis media.
Post-Marketing Experience
As with any vaccine, there is the possibility that broad use of COMVAX could reveal adverse experiences not observed in clinical trials. The following additional adverse reactions have been reported with the use of the marketed vaccine.
Hypersensitivity
Anaphylaxis, angioedema, urticaria, erythema multiforme
Hematologic
Thrombocytopenia
Nervous System
Seizure, febrile seizures
Potential Adverse Effects
In addition, a variety of adverse effects have been reported with marketed use of either PedvaxHIB or RECOMBIVAX HB in infants and children through 71 months of age. These adverse effects are listed below.
PedvaxHIB
Hematologic/Lymphatic
Lymphadenopathy
Skin
Sterile injection-site abscess; pain at the injection site
RECOMBIVAX HB
Hypersensitivity
Symptoms of hypersensitivity including reports of rash, pruritus, edema, arthralgia, dyspnea, hypotension, and ecchymoses
Cardiovascular System
Tachycardia; syncope
Digestive System
Elevation of liver enzymes
Hematologic
Increased erythrocyte sedimentation rate
Musculoskeletal System
Arthritis
Nervous System
Bell's Palsy; Guillain-Barré Syndrome
Psychiatric/Behavioral
Agitation; somnolence; irritability
Skin
Stevens-Johnson Syndrome; alopecia
Special Senses
Conjunctivitis; visual disturbances
Adverse Event Reporting
Patients, parents and guardians should be instructed to report any serious adverse reactions to their health-care provider who in turn should report such events to the U.S. Department of Health and Human Services through the Vaccine Adverse Event Reporting System (VAERS), 1-800-822-7967. The healthcare provider should inform the parent or guardian of the National Vaccine Injury Compensation Program (NVICP), 1-800-338-2382.
http://us.gsk.com/products/assets/us_engerixb.pdf
Pages 6-8
6 ADVERSE REACTIONS
6.1 Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a vaccine cannot be directly compared to rates in the clinical trials of another vaccine and may not reflect the rates observed in practice.
The most common solicited adverse events were injection site soreness (22%) and fatigue (14%).
In 36 clinical studies, a total of 13,495 doses of ENGERIX-B were administered to 5,071 healthy adults and children who were initially seronegative for hepatitis B markers, and healthy neonates. All subjects were monitored for 4 days post-administration. Frequency of adverse events tended to decrease with successive doses of ENGERIX-B.
Using a symptom checklist, the most frequently reported adverse events were injection site soreness (22%) and fatigue (14%). Other events are listed below. Parent or guardian completed forms for children and neonates. Neonatal checklist did not include headache, fatigue, or dizziness.
Incidence 1% to 10% of Injections: Nervous System Disorders: Dizziness, headache.
General Disorders and Administration Site Conditions: Fever (>37.5°C), injection site erythema, injection site induration, injection site swelling.
Incidence 1% of Injections: Infections and Infestations: Upper respiratory tract illnesses.
Blood and Lymphatic System Disorders: Lymphadenopathy.
Metabolism and Nutrition Disorders: Anorexia.
Psychiatric Disorders: Agitation, insomnia.
Nervous System Disorders: Somnolence, tingling.
Vascular Disorders: Flushing, hypotension.
Gastrointestinal Disorders: Abdominal pain/cramps, constipation, diarrhea, nausea, vomiting.
Skin and Subcutaneous Tissue Disorders: Erythema, petechiae, pruritus, rash, sweating, urticaria.
Musculoskeletal and Connective Tissue Disorders: Arthralgia, back pain, myalgia, pain/stiffness in arm, shoulder, or neck.
General Disorders and Administration Site Conditions: Chills, influenza-like symptoms, injection site ecchymosis, injection site pain, injection site pruritus, irritability, malaise, weakness.
6.2 Postmarketing Experience
In addition to reports in clinical trials, worldwide voluntary reports of adverse events received for ENGERIX-B since market introduction (1990) are listed below. This list includes serious adverse events or events which have a suspected causal connection to components of ENGERIX-B.
The following adverse events have been identified during postapproval use of ENGERIX-B. Because these events are reported voluntarily from a population of unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to the vaccine. [yeah right !!]
Infections and Infestations: Herpes zoster, meningitis.
Blood and Lymphatic System Disorders: Thrombocytopenia.
Immune System Disorders: Allergic reaction, anaphylactoid reaction, anaphylaxis. An apparent hypersensitivity syndrome (serum sickness-like) of delayed onset has been reported days to weeks after vaccination, including: arthralgia/arthritis (usually transient), fever, and ermatologic reactions such as urticaria, erythema multiforme, ecchymoses, and erythema nodosum.
Nervous System Disorders: Encephalitis, encephalopathy, migraine, multiple sclerosis, neuritis, neuropathy including hypoesthesia, paresthesia, Guillain-BarrĂ© syndrome and Bell’s palsy, optic neuritis, paralysis, paresis, seizures, syncope, transverse myelitis.
Eye Disorders: Conjunctivitis, keratitis, visual disturbances.
Ear and Labyrinth Disorders: Earache, tinnitus, vertigo.
Cardiac Disorders: Palpitations, tachycardia.
Vascular Disorders: Vasculitis.
Respiratory, Thoracic and Mediastinal Disorders: Apnea, bronchospasm including asthma-like symptoms.
Gastrointestinal Disorders: Dyspepsia.
Skin and Subcutaneous Tissue Disorders: Alopecia, angioedema, eczema, erythema multiforme including Stevens-Johnson syndrome, erythema nodosum, lichen planus, purpura.
Musculoskeletal and Connective Tissue Disorders: Arthritis, muscular weakness.
General Disorders and Administration Site Conditions: Injection site reaction.
Investigations: Abnormal liver function tests.
VACCINES HAVE NEVER PREVENTED ANY DISEASES EVER! BUT AS THE PACKAGE INSERTS DIRECT FROM pHARMa COMPANIES PROOVE, THEY CAUSE DISEASES!
ARE YOU GETTING IT YET??!!
http://www.examiner.com/article/list-of-links-where-you-can-find-out-what-vaccine-package-inserts-say
http://www.vaclib.org/chapter/inserts.htm
http://www.vaccinesafety.edu/package_inserts.htm
Exemptions are freely available:
http://www.vaclib.org/exemption.htm
http://www.vaccinetruth.net/
http://www.vaclib.org/legal/stateresource.htm
Texas Billboard
Watch for this billboard (Thursday, August 9 2012). It will be viewable on Northbound IH-35 in Austin TX, on the Upper Deck at 30th Street. Thanks to Shawn Siegel for making this billboard happen. Listen to Shawn's new show, "The Vaccine Myth: An Issue of Trust" on Sundays from 2 to 4 PM CST at 90.1 FM in Austin, and streaming live at http://logosradionetwork.com/.
Click below for a recording of Shawn's first show!
https://www.youtube.com/watch?v=FKZoknv_QN4
------------------------------------------------------------------------
http://www.vaclib.org/
http://www.vaccinetruth.net/
Sunday, August 5, 2012
Juicing and Raw Foods: The Klinghardt Neurotoxin Elimination Protocol
Juicing and Raw Foods: The Klinghardt Neurotoxin Elimination Protocol: The Klinghardt Neurotoxin Elimination Protocol Approved by: American Academy of Neural Therapy and Institute of Neurobiology (Bellevue, WA, USA)
Institute for Neurobiologie (Stuttgart, Germany)
Academy for Balanced NeuroBiology Ltd (London, United Kingdom) This lecture was presented by Dietrich Klinghardt M.D., Ph.D. at the Jean Piaget Department at the University of Geneva, Switzerland Oct. 2002 to physicians and dentists from Europe, Israel, several Arab countries and Asia...
Institute for Neurobiologie (Stuttgart, Germany)
Academy for Balanced NeuroBiology Ltd (London, United Kingdom) This lecture was presented by Dietrich Klinghardt M.D., Ph.D. at the Jean Piaget Department at the University of Geneva, Switzerland Oct. 2002 to physicians and dentists from Europe, Israel, several Arab countries and Asia...
The Daily Messenger: Evidence Implicating Amalgam in Alzheimer's Diseas...
The Daily Messenger: Evidence Implicating Amalgam in Alzheimer's Diseas...: Excerpts from memo by Kip Sullivan -------------------------------------------------------------------------------- Studies have 4-times as much mercury and 2-times as much aluminum as is found in patients without Alzheimer. Also, tumors contain more mercury than is found in their environment...
Saturday, August 4, 2012
Juicing and Raw Foods: Mainstream media pushes malicious fluoride lie: Fl...
Juicing and Raw Foods: Mainstream media pushes malicious fluoride lie: Fl...: NaturalNews) The mainstream media is at it again, lying to the public about fluoride. This time, the culprit is HealthDay, a "canned news" service that spits out lies and disinformation to be published by subscribing websites...
______________________________________________________
Thank God for well water here.
______________________________________________________
Thank God for well water here.
California - Study: Whooping cough outbreak linked to vaccinated children
http://www.digitaljournal.com/article/323187#ixzz1sxmUPPKh
California - Study: Whooping cough outbreak linked to vaccinated children
"After examining the records of juvenile whooping cough patients over an 8-month period, the doctors discovered that 81 percent of patients had received the full series of whooping cough shots, and 11 percent had received only some of the shots. The remaining 8 percent had not received any immunizations for whooping cough.
"What was very surprising was the majority of cases were in fully vaccinated children," Witt said. "That's what started catching our attention.
AND LOOK AT THIS "Unfortunately, drug maker Glaxo Smith Kline (GSK), the manufacturer of the whooping cough vaccine, did not bother to perform long-term studies of its effectiveness. A company spokesperson confirmed this disturbing fact in an email to Reuters, stating that GSK never studied the duration of the vaccine's protection after the shot was given to four- to six-year-olds"
AND
"Revelations like these should be a reminder to parents to do as much research as possible and weigh the risks and benefits before allowing their children to receive vaccines. "
California - Study: Whooping cough outbreak linked to vaccinated children
"After examining the records of juvenile whooping cough patients over an 8-month period, the doctors discovered that 81 percent of patients had received the full series of whooping cough shots, and 11 percent had received only some of the shots. The remaining 8 percent had not received any immunizations for whooping cough.
"What was very surprising was the majority of cases were in fully vaccinated children," Witt said. "That's what started catching our attention.
AND LOOK AT THIS "Unfortunately, drug maker Glaxo Smith Kline (GSK), the manufacturer of the whooping cough vaccine, did not bother to perform long-term studies of its effectiveness. A company spokesperson confirmed this disturbing fact in an email to Reuters, stating that GSK never studied the duration of the vaccine's protection after the shot was given to four- to six-year-olds"
AND
"Revelations like these should be a reminder to parents to do as much research as possible and weigh the risks and benefits before allowing their children to receive vaccines. "
Thursday, August 2, 2012
NCR Second Session
Had awesome results this NCR session as well.
I gained an inch in height this session, so that puts me at 5' 7'. I had gained an inch due to a series of ROLFing sessions back in late 2009-early 2010.
Here are the pics of the before and after of the first session. Now the grid on the wall didn't move. I did. Look at where my head and eyes, etc... line up to the grid lines compared to the earlier pics. And I was also having some serious collapsed face, palate, and skull issues before I started. No wonder I was in a constant headache!
Again, these are not glamour shots, and I was supposed to have a serious look on my face. They told me to look real serious and not smile. For diagnostic purposes, I suppose. So I'm not pissed off here.
To show you the height, check out this god awful no makeup pic. I posed here to show off my height after getting back home from the session. That was the last day of the session.
We also got to visit the lovely Pacific again, so here's a better pic where I don't look pissed off. It was a beautiful day, and we took a walk on the beach.
Although I look like a different person in the latter pic, it's really not so much looking like a different person. I just look like I did 20 years ago. Think of the tent poles in a tent being re-erected. I basically had the tent poles in my face and head re-erected, so to speak.
For more info on the naturopathic doctor who did my NCR, go to http://www.nwncr.com/ and look up Dr. Hillary Lampers, ND.
To find one in your area, go to http://www.ncrdoctors.com/ and click on find practitioner.
I gained an inch in height this session, so that puts me at 5' 7'. I had gained an inch due to a series of ROLFing sessions back in late 2009-early 2010.
Here are the pics of the before and after of the first session. Now the grid on the wall didn't move. I did. Look at where my head and eyes, etc... line up to the grid lines compared to the earlier pics. And I was also having some serious collapsed face, palate, and skull issues before I started. No wonder I was in a constant headache!
Again, these are not glamour shots, and I was supposed to have a serious look on my face. They told me to look real serious and not smile. For diagnostic purposes, I suppose. So I'm not pissed off here.
To show you the height, check out this god awful no makeup pic. I posed here to show off my height after getting back home from the session. That was the last day of the session.
We also got to visit the lovely Pacific again, so here's a better pic where I don't look pissed off. It was a beautiful day, and we took a walk on the beach.
Although I look like a different person in the latter pic, it's really not so much looking like a different person. I just look like I did 20 years ago. Think of the tent poles in a tent being re-erected. I basically had the tent poles in my face and head re-erected, so to speak.
For more info on the naturopathic doctor who did my NCR, go to http://www.nwncr.com/ and look up Dr. Hillary Lampers, ND.
To find one in your area, go to http://www.ncrdoctors.com/ and click on find practitioner.
Wednesday, August 1, 2012
Wednesday, July 25, 2012
Juicing and Raw Foods: Massive outbreak of whooping cough proves vaccine is ineffective
Juicing and Raw Foods: Massive outbreak of whooping cough proves vaccine is ineffective ...: (NaturalNews) Whooping cough - otherwise known as Pertussis - is looking to make a rather nasty comeback this year. So much so that health officials are already warning of the danger...
Vitamin B-12 Methylcobalamin vs Cyancolbalamin
Health advocates all around the world are throwing their B-12 supplements in the trash and replacing them with these Human Active B-12 Patches. Cyanocobalamin is a non-human active B-12 which is actually bound to a toxic Cyan!de molecule and is used in many of the B-12 supplements on the market. Unfortunately, in some people, new research now shows that Cyanocobalamin can actually rob them of their B-12 methyl groups, which can leave their B-12 levels even worse.
Methylcobalamin is a human active B-12, which is found in nature and has the potential to raise our B-12 levels like nothing else. We have found that besides taking B-12 shots, these B-12 patches are the most effective B-12 on the market for helping maintain healthy B-12 levels.
The better choice: Methylcobalamin
The proper form of vitamin B-12 to supplement is called methylcobalamin. This is the form that exists in nature, and it is pre-methylated, meaning it's ready for your biochemistry to put to immediate use. Methylcobalamin has several key advantages over cyanocobalamin:
* Increased absorption
* Better retention in tissues
* Contains no toxic cyanide
* Supports production of SAMe
LATEST RESEARCH - Methylcobalamin
http://www.globalhealingcenter.com/newsletter/2000/june/articles.php?id=1
What is the difference between Cyanocobalamin and Methylcobalamin? Methylcobalamin is the active form of vitamin B-12 that is better absorbed than many of the other forms like cyanocobalamin. Actually, Vitamin B12 comes in several kinds including hydroxy-, cyano-, and adenosyl-, but only the methyl form is used in the central nervous system.
Here are some of the many uses and benefits of Methylcobalin The methyl form of B-12 especially protects nerve tissue and brain cells, and promotes healthy sleep.
Methylcobalamin is important because it is delivered more efficiently to nerve tissues than regular B-12. Because of this, Methylcobalamin should be considered in the treatment of all neurological diseases.
Based on its mechanism of action, it can be effective in slowing the progression of hard to treat neurological diseases like ALS, Multiple Sclerosis and Parkinson's Disease. Published studies show that high doses can help regenerate neurons and the myelin sheath that protects axons and peripheral nerves. Theraputic doses of Methylcobalamin have also been known to prevent and reverse numbness from nerve damage.
Among the conditions which have responded favorably to Methylcobalamin are, ALS (Lou Gehrig's Disease,) Alzheimer's disease, Bell's Palsy, Parkinson's disease, Multiple Sclerosis, Brain Aging, Insomnia, Immune dysfunction, Chronic Fatigue Syndrome and Fibromyalgia, Schizophrenia, Diabetes, Impotence and Herpes Zoster (Shingles.)
In one study of Alzheimer's patients given Methylcobalamin, the subjects improved their memory, emotions, and ability to communicate. In Alzheimer's or suspected Mercury amalgam related diseases (e.g. MS,) a hidden Vitamin B-12 deficiency has been found, even though the usual blood tests are normal. In one study of patients with chronic, progressive Multiple Sclerosis, 60 mg of Methylcobalamin resulted in clinical improvement in visual and auditory function, but not motor disability.
Methylcobalamin may help prevent Parkinson's disease and slow the progression in those who are already afflicted. Parkinson's is caused by a destruction of brain cells that produce dopamine. Dopamine is produced from the amino acid, L-Dopa. Anyone taking any form of L-Dopa should also take from 5 to 20 mg of Methylcobalamin to enjoy the benefits of L-Dopa for much longer. For best results, it should be taken with Alpha Lipoic Acid. In a sleep study it was shown that Methylcobalamin reduced the amount of time the subjects slept, but the sleep quality was better and subjects awakened refreshed with better alertness and concentration.
Methylcobalamin at 6mg per day for 16 weeks also improved sperm count by 37.5 percent.
In other studies it was found that Methylcobalamin enhances and modulates lymphocytes (white blood cells) by increasing T-Cell (and especially T-helper cells) activity.
In mice, several different kinds of cancerous tumors were suppressed by administration of Methylcobalamin for seven days. These included liver, lung and other tumors.
In a study of Amyotrophic Lateral Sclerosis (ALS) patients, all given high dose (25 mg per day) Methylcobalamin showed increases in muscle strength. Methylcobalamin also slows the progression to AIDS in HIV + patients and helps prevent neurological problems. Methylcobalamin also balances the sympathetic/parasympathetic nervous system (calming when overexcited and stimulating when too calm).
A therapeutic dose for conditions requiring Methylcobalamin would be a minimum of 1500 mcg and a maximum of 6000 mcg per day. No significant therapeutic advantage appears to occur from dosages exceeding this maximum dose; however, it is likely that beneficial physiological effects occur at dosages as low as 100 mcg per day, especially if this dose is given repetitively over time. Methylcobalamin is usually administered in divided doses three times daily. For every day prevention take 1 mg daily under the tongue.
Dr. Edward F. Group III
Cyanocobalamin Versus Methylcobalamin
QUESTION: What is the difference between what you call the "active form" of B12 and the standard health food store/ pharmacy brand. Aren't they both "active?"
ANSWER: Cyanocobalamin is the most commonly supplemented form of vitamin B12, but you might be surprised to discover that this form of vitamin B12 does not actually occur in plants or animal tissues. In other words, outside of the chemically synthesized cyanocobalamin that you encounter as B12 in most vitamin supplements, you would be extremely hard pressed to find this compound in nature (in fact you would not be able to find it). As the name implies, cyanocobalamin contains a cyanide molecule. Most people are familiar with cyanide as a poisonous substance. Although the amount of cyanide in a normal B12 supplement is small and from a toxicology point, viewed as insignificant, your body will still need to remove and eliminate this compound. This removal is accomplished through your detoxification systems with substances like glutathione being very important for the elimination of the cyanide.
Compared with cyanocobalamin, it appears that methylcobalamin is better absorbed and retained in higher amounts within your tissues. In simple terms, they are used much more effectively. In general, methylcobalamin is used primarily in your liver, brain and nervous system.
Methylcobalamin is the specific form of B12 needed for nervous system health. Because of this it should be the first form of this vitamin thought of when interested in attempting to optimize the health of the nervous system with vitamin supplementation. Indications of a potential deficiency of B12 in the nervous system might include numbness, tingling, loss of feeling sensation, burning sensations, muscle cramps, nerve pain and slowness of reflexes.
Because of methylcobalamin's importance in nervous system health, it is also an important nutrient for vision. In fact, continued visual work (like work on a computer) often leads to a reduction in something called "visual accommodation". Methylcobalamin can significantly improve visual accommodation, while cyanocobalamin appears to be ineffective.
An elevated level of homocysteine is a metabolic indication of decreased levels of the coenzyme forms of vitamin B12, especially methylcobalamin. Homocysteine has received a tremendous amount of emphasis in the scientific literature because of its associations with heart disease and a variety of other specific health conditions. I have even seen advertisements on television promoting folic acid, as a vitamin needed to lower homocysteine. While this is true, and folic acid does lower homocysteine levels, the combination of methylcobalamin and folic acid appears to work much better.
The most well studied use of methylcobalamin has to do with sleep. Although the exact mechanism of action is not yet clear, it is possible that methylcobalamin is needed for the synthesis of melatonin. Available information indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalize circadian rhythm (your 24-hour clock). Because of this, individuals supplementing this form of B12 often have improved quality of sleep, often will require slightly less sleep, and will not uncommonly report that they feel a bit more refreshed when waking in the morning. Methylcobalamin is particularly effective when your 24-hour clock is not running smoothly. This may be indicated by a need for excessive sleep, changing sleep-wake cycles, or a tendency to have altered sleep wake patterns. As examples, you might require 10-12 hours of sleep, or you might not feel tired until 2-3 am and you might wake at noon, or you might find that you wake a bit later every day and go to be a bit later every night. Under all of these circumstances the combination of methylcobalamin (about 3000 mcg daily) and exposure to bright light in the morning can help reestablish your 24-hour clock.
Because of methylcobalamin's impact on 24-hour clock and the cycles that feed of this, it is also an important vitamin to regulate your 24-hour release of the stress hormone cortisol. This seems to be particularly important for blood types A and AB. Methylcobalamin also seems to result in a better 24-hour maintenance of body temperature. Typically individuals supplementing this coenzyme form of B12 have higher temperatures in the later hours of the daytime. This usually corresponds with improved alertness at the same time of the day. While this can be of importance to all blood types, low body temperatures seems to be an area of greater challenge for A's and B's.
Vitamin B12: All Cobalamins are not Equal
From http://www.strokedoctor.com/vitamin_b12.htm
"Vitamin B12: All Cobalamins are not Equal
Look at your multiple vitamin or B complex bottle. You're probably taking cyanocobalamin, the stable and less expensive form of vitamin B12. Because it is stable, it has a longer shelf life. However, the active form of B12 is methylcobalamin and the two are NOT equal in effectiveness. If you have symptoms of GI disorders, lethargy, confusion, slow thought processes, heart rate variability, atherosclerosis, sleep disorders, or immune dysfunction, you may need the methyl as well as the cobalamin component.
The two vitamin B12 coenzymes known to be metabolically active in humans are methylcobalamin and adenosylcobalamin. Vitamin B12 is usually absorbed from the gut from the fermentation of intrinsic factor by intestinal flora. However, production can be disturbed by nutritional deficiencies, intrinsic factor deficiency, bacterial overgrowth, malabsorption, alcohol, and antibiotics. Nitrous oxide anesthesia in surgery and nitric acid from normal metabolism and inflammation also reduce our vitamin B12 levels.
Cobalamins are destroyed by heavy metals and strong oxidizing or reducing agents. (take at different times than vit c). Vitamin B12 deficiency generally increases with age and is common in the elderly.(2)
Both vitamin B12 and folic acid are required for the synthesis of thymidylate, a component of DNA. Lack of adequate DNA synthesis causes many red blood cell precursors (hematopoietic cells) to die in the bone marrow. The development of epithelial cells is also disturbed by thymidylate deficiency. Gut changes due to vitamin B12 deficiency are often related to constipation whereas a folic acid deficiency is generally related to diarrhea. In the brain, the arrest of cell replication due to vitamin B12 deficiency disrupts myelin synthesis, resulting in neural damage in the brain, spinal cord and/or peripheral nerves. Vitamin B12 deficiency can include the following neurological symptoms: numbness and tingling in the hands and feet, unsteadiness, poor muscular coordination, moodiness, mental slowness, poor memory, confusion, agitation, and/or depression.
Vitamin B12 is involved in fat and carbohydrate metabolism. It is required in the synthesis of the amino acid methionine, which is involved in choline and betaine utilization. B12 assists in maintaining sulfhydryl (SH) groups in their reduced form for enzyme activity. Vitamin B12 deficiency is associated with a decrease of reduced glutathione, needed for cell defense against pathogens (viruses, bacteria, fungi) and toxins.
Methylcobalamin is a co-factor of methionine synthase, an enzyme that transfers methyl groups to homocysteine to regenerate methionine. Elevated homocysteine levels are a risk factor for coronary artery disease. (11) Methionine can be transformed to S-adenoxylmethionine (SAM) that is involved in a variety of methylation reactions in the body, one of which is alleviating depression.(13)
Methylcobalamin also plays a role in cell-mediated and humoral immune function in rats. In vitamin B12 deficient rats, serum C3, IgM and Ig G factors were found to be lower. There was also an elevation of the ratio of CD4+ CD8- to DC4- CD8+, which reduces the ability to fight off pathogens.(12)
Cyanocobalamin is not biologically active until converted to methylcobalamin, which also means releasing its cyanide. Cyanide can be toxic because it binds the iron (F3+) portion of cytochrome oxidases, preventing its reduction. This binding blocks electron transport and interrupts cellular respiration. Symptoms of sublethal cyanide toxicity include hypotension, tachypnea, and tachycardia.(4)
Cobalamin can bind with cyanide and is therefore effective in reducing cyanide toxicity. However cyanocobalamin is not effective in removing cyanide because the cobalamin is already bound. (3) Since nitroprusside can induce cyanide toxicity, other cobalamins such as hydroxocobalamin should be used to bind with cyanide. Nitroprusside therapies should be minimized in critically ill patients and those with liver or kidney dysfunction.
Large amounts of cyanocobalamin can exacerbate preexisting cyanide toxicity that can result from smoking tobacco, sodium nitroprusside therapy, and phagocytosis. Steve Roach, M.D. writes that "it seems wise to avoid a potentially harmful form of a drug when the more physiologic variety is available and is excreted at a more desirable rate.(7)
Foods fortified with vitamin B12 (as cyanocobalamin) may be a potential problem if cooked. The highest mutation activity in cooked (pyrolysate) vitamins was found in cyanocobalamin (3220 revertants at .025 mumole of cyanocobalamin).(5)
In a comparison of cobalamins against cancer, adenoxylcobalamin was effective against fast-growing malignant cells. Methylcobalamin was effective at elevated concentrations and cyanocobalamin had no effect in slowing the growth of any of the tumor cell lines studied.(6) In studies that show that vitamin B12 has no effect on cancer growth, we need to look closer at whether cyanocobalamin was used instead of the natural coenzyme forms (adenoxylcobalamin and methylcobalamin).
Methylcobalamin enhances synaptic transmission in learning and memory. Ikeuchi and associates studied the effects of methyl-B12 on the electrical activity in hippocampal neurons and found that methyl-B12 increased post-synaptic field potential which lasted more than an hour and increased the electrical currents elicited by N-methyl-D-aspartate (NMDA). Cyanocobalamin had no effect.(13)
Methylcobalamin plays a role in modulating human circadian rhythms. It accelerates re-entrainment of the activity rhythm to the environmental light-dark cycle. The suprachiasmatic nucleus (SCN) is involved in relaying photic information to the pineal gland. Methylcobalamin enhanced the field potential in the SCN that lasted an hour. In contrast, cyanocobalamin showed no effect.(16)
Methylcobalamin is also required in donating a methyl group for the synthesis of melatonin. Methylcobalamin supplementation can assist in modulating melatonin secretion, enhancing light-sensitivity, normalizing circadian rhythms and improving sleep-wake cycles. (17)
Methylcobalamin also helps improve heart rate variability, suggesting that it is involved in balancing sympathetic and parasympathetic nervous system function,(18) perhaps through its involvement with light entrainment and melatonin synthesis. Since circadian rhythm and melatonin synthesis are key factors in health maintenance, the use of cyanocobalamin rather than methylcobalamin is undermining our health as individuals as well as a nation.
Another study found a correlation between serum vitamin B12 in women and their breast milk. When a group of lactating women were injected with cyanocobalamin, there was also an increase of cyanocobalamin in their breast milk.
As early as 1970, Dr. A.G. Freeman protested against the use of cyanocobalamin in The Lancet. He again wrote a letter in 1978, entitled "Why Has Cyanocobalamin Not Been Withdrawn?" to The Lancet and to the British Committee on Safety of Drugs. Dr. Freeman voiced the concern that even if hydroxocobalamin is prescribed, cyanocobalamin is administered in its place. They wrote that "because doctors are still confused about the differences between various forms of vitamin B12 commercially available and about their possible adverse effects, manufacturers should withdraw cyanocobalamin in favor of hydroxocobalamin for therapeutic use." (8)
A letter from Dr. Terry was published in the October, 1978 issue of The Lancet. He wrote that "the lead for improved prescribing must come form compilers of formularies that are highly regarded. In this respect it is disappointing to find that the W.H.O. expert committee on the selection of essentiald rugs lists only cyanocobalamin, placing an incalculable number of patients with optic neuropathy in pernicious anemia or tobacco and tropical amblyopia at risk." (9)
In the November 1978 issue, the Lancet published a letter by J.C.Linnell and associates entitled "Therapeutic Misuse of Cyanocobalamin." The authors state that cyanocobalamin itself has no known biochemical function. Only trace amounts of cyanocobalmin are normally detectable in the human body, while significant amounts occur in patients with optic neuropathies, inborn errors of cobalamin metabolism and pernicious anemia. Cyanocobalamin must first undergo conversion to the physiological forms of cobalamin before being effective against pernicious anemia. However hydroxocobalamin (a precursor to methyl and andenoxylcobalamin) "has the additional advantage of therapeutic efficacy in certain neuropathies and some cases of inborn errors of cobalamin metabolism." The authors further write that "it is lamentable that an extensive demand for cyanocobalamin as a therapeutic agent should persist. There seems to be no place for the continued therapeutic use of cyanocobalamin." (10)
Vitamin B12 is found in algae, peas, clover, alfalfa, mustard, egg yolk, chedder cheese, sardines, herring, anchovies, calve's liver, haddock, salmon, and cow's milk. Plants containing S-methylmethionine include cabbage, kohlrabi, turnip, tomatoes, celery, leeks, garlic, beets, raspberries and strawberries (14). Cyanocobalamin is in haddock and cassava root. Elevated amounts of cyanocobalamin have been found in smokers and cases of amyotrophic lateral sclerosis and optic atrophy.
Clinical doses of methylcobalamin are 1500-6000 mcg per day and can be administered orally, intramuscularly or intravenously with positive clinical results. Methylcobalamin is well tolerated and has no known toxicity. B complex (riboflavin, folic acid, pyridoxine, and choline), and zinc assist methylcobalamin effectiveness. It is important that physicians giving injections check the source of their vitamin B12. Not only can it be cyano rather than methylcobalamin, but the shot gun approach of giving liver extract can include allergenics. One report states that 10-30% of pharmaceutical preparations may be noncobalamin analogues, that are either inactive or cause allergic reactions. (1)
In conclusion, methylcobalamin can be effective in cases of neuropathy, depression, cancer, optic atrophy, heart rate variability, homocysteinemia, and sleep disturbances. However, all cobalamin analogues are not equal and taking cyanocobalamin with already elevated levels of cyanide can actually be harmful. It has been thirty years since Dr. Freeman first published a letter in The Lancet about the risks of using cyanocobalamin. How much longer can we afford to allow ignorance and profit motives to undermine our nation's health?
REFERENCES:
(1) Herbert, Victor and Neville Colman. "Folic Acid and Vitamin B12" in Shils, Maurice and Vernon R. Young, "Modern Nutrition in Health and Disease." Lea & Febinger, Philadelphia, PA, 1988, pg. 388-416.
(2) Watt, D.T. "Vitamin B12 replacement therapy: how much is enough?" Wisconsin Medical Journal, 1994, 93(5): 203- 5.
(3) Zerbe, N.F. et al. "Use of vitamin B12 in the treatment and prevention of nitroprusside-induced cyanide toxicity." Critical Care Medicine, 1993, 21(3): 465-7.
(4) Williams, H.L. et al. "Studies of cobalamin vehicle for the renal excretion of cyanide anion." Journal of Laboratoyr and Clinical Medicine, 1990, 116(1): 37-44.
(5) Demura, R. et al. "Mutagenic activity of pyrolysate of cyanocobalamin and some other soluble vitamins in the model system with the Salmonella/mammalian microsomes." Mutation Research, 1990, 244(1): 37-42.
(6) Tsao, C.S. et al. "Cytotoxic activity of cobalamin in cultured malignant and nonmalignant cells." Pathobiology, 1990, 58(5): 292-6.
(7) Sawyer, D.R. "Cyanocobalmin and cyanide toxicity (letter)." American Family Physician, 1982, 26(1): 48.50,55.
(8) Freeman, A.G. et al. "Why has cyanocobalamin not been withdrawn?" The Lancet, April 8, 1978; pg. 777-778.
(9) Terry, S.I. et al. "Survival of Cyanocobalmin." The Lancet, October 14, 1978, pg. 848.
(10) Linnell, J.C. et al. "Therapeutic Misuse of Cyanocobalamin". Lancet, November 11, 1978; pg 1053-1054.
(11) Brown, C.A. et al. "A Common Polymorphism in Methionine Synthase Reductase Increases Risk of Premature Coronary Artery Disease." J Cardiovasc Risk 2000, 7(3): 197-200.
(12) Funada, U. et al. "Changes in CD4+ CD8-/CD4- CD8+ ratio and humoral immune functions in vitamin B12-deficient rats." Int J Vitam Nutr Res, 2000, 70(4): 167-71.
(13) Ikeuchi, Youji et al. "Methylcobalamin induces a long-lasting enhancement of the postsynaptic field potential in hippocampal slices of the guinea pig." Neuroscience Leters, 1995, 192: 113-116.
(14) Kovatscheva, E.G. et al. "S-methylmethionine content in plant and animal tissues and stability during storage." Nahrung, 1977, 21(6): 465-72.
(15) Schneider, Z. "Comprehensive B12." Walter de Gruyter, New York, New York, 1987.
(16) Nishikawa, Yukiko et al. "Methylcobalamin induces a long-lasting enhancement of the field potential in rat suprachiasmatic nucleus slices." Neuroscience Letters, 1996: 220: 199-202.
(17) Mayer, G. et al. "Effects of vitamin B12 on performance and circadian rhythm in normal subjects." Neuropsychopharmacology, 1996; 15: 456-464.
(18) Yoshioka, K. et al. "Effect of methylcobalamin on diabetic autonomic neuropathy as assessed by power spectral analysis of heart rate variations." Horm Metab Res, 1995, 27: 43-44"
__________________________________________________
The following supplements contain the Methylated form of B-12 Methylcobalamin:
intraMAX® from Life Enthusiast Co-op
intraKID™
Note: IntraMax & IntraKid now contains both cyanocobalamin AND methylcobalamin. To be on the safe side, take an extra methylcobalamin supplement, like one of the ones below.
Sublingual B-12 (Methylcobalamin)
Tangy Tangerine (Vitamins & colloidal minerals) buy from Youngevity Online
SUBLINGUAL B12 VITAMIN from Bio-Alternatives
INGREDIENTS: Vitamin B12 (Methylcobalamin) in Pure Water
SUPPLEMENT FACTS:
Serving Size - 1/2 dropper (1000 mcg)
Servings per Container - 60
SUGGESTED USE: As a Dietary Supplement 1/2 dropper once or twice daily.
CardioForLife®
More choices coming soon...
-
Methylcobalamin is a human active B-12, which is found in nature and has the potential to raise our B-12 levels like nothing else. We have found that besides taking B-12 shots, these B-12 patches are the most effective B-12 on the market for helping maintain healthy B-12 levels.
The better choice: Methylcobalamin
The proper form of vitamin B-12 to supplement is called methylcobalamin. This is the form that exists in nature, and it is pre-methylated, meaning it's ready for your biochemistry to put to immediate use. Methylcobalamin has several key advantages over cyanocobalamin:
* Increased absorption
* Better retention in tissues
* Contains no toxic cyanide
* Supports production of SAMe
LATEST RESEARCH - Methylcobalamin
http://www.globalhealingcenter.com/newsletter/2000/june/articles.php?id=1
What is the difference between Cyanocobalamin and Methylcobalamin? Methylcobalamin is the active form of vitamin B-12 that is better absorbed than many of the other forms like cyanocobalamin. Actually, Vitamin B12 comes in several kinds including hydroxy-, cyano-, and adenosyl-, but only the methyl form is used in the central nervous system.
Here are some of the many uses and benefits of Methylcobalin The methyl form of B-12 especially protects nerve tissue and brain cells, and promotes healthy sleep.
Methylcobalamin is important because it is delivered more efficiently to nerve tissues than regular B-12. Because of this, Methylcobalamin should be considered in the treatment of all neurological diseases.
Based on its mechanism of action, it can be effective in slowing the progression of hard to treat neurological diseases like ALS, Multiple Sclerosis and Parkinson's Disease. Published studies show that high doses can help regenerate neurons and the myelin sheath that protects axons and peripheral nerves. Theraputic doses of Methylcobalamin have also been known to prevent and reverse numbness from nerve damage.
Among the conditions which have responded favorably to Methylcobalamin are, ALS (Lou Gehrig's Disease,) Alzheimer's disease, Bell's Palsy, Parkinson's disease, Multiple Sclerosis, Brain Aging, Insomnia, Immune dysfunction, Chronic Fatigue Syndrome and Fibromyalgia, Schizophrenia, Diabetes, Impotence and Herpes Zoster (Shingles.)
In one study of Alzheimer's patients given Methylcobalamin, the subjects improved their memory, emotions, and ability to communicate. In Alzheimer's or suspected Mercury amalgam related diseases (e.g. MS,) a hidden Vitamin B-12 deficiency has been found, even though the usual blood tests are normal. In one study of patients with chronic, progressive Multiple Sclerosis, 60 mg of Methylcobalamin resulted in clinical improvement in visual and auditory function, but not motor disability.
Methylcobalamin may help prevent Parkinson's disease and slow the progression in those who are already afflicted. Parkinson's is caused by a destruction of brain cells that produce dopamine. Dopamine is produced from the amino acid, L-Dopa. Anyone taking any form of L-Dopa should also take from 5 to 20 mg of Methylcobalamin to enjoy the benefits of L-Dopa for much longer. For best results, it should be taken with Alpha Lipoic Acid. In a sleep study it was shown that Methylcobalamin reduced the amount of time the subjects slept, but the sleep quality was better and subjects awakened refreshed with better alertness and concentration.
Methylcobalamin at 6mg per day for 16 weeks also improved sperm count by 37.5 percent.
In other studies it was found that Methylcobalamin enhances and modulates lymphocytes (white blood cells) by increasing T-Cell (and especially T-helper cells) activity.
In mice, several different kinds of cancerous tumors were suppressed by administration of Methylcobalamin for seven days. These included liver, lung and other tumors.
In a study of Amyotrophic Lateral Sclerosis (ALS) patients, all given high dose (25 mg per day) Methylcobalamin showed increases in muscle strength. Methylcobalamin also slows the progression to AIDS in HIV + patients and helps prevent neurological problems. Methylcobalamin also balances the sympathetic/parasympathetic nervous system (calming when overexcited and stimulating when too calm).
A therapeutic dose for conditions requiring Methylcobalamin would be a minimum of 1500 mcg and a maximum of 6000 mcg per day. No significant therapeutic advantage appears to occur from dosages exceeding this maximum dose; however, it is likely that beneficial physiological effects occur at dosages as low as 100 mcg per day, especially if this dose is given repetitively over time. Methylcobalamin is usually administered in divided doses three times daily. For every day prevention take 1 mg daily under the tongue.
Dr. Edward F. Group III
Cyanocobalamin Versus Methylcobalamin
QUESTION: What is the difference between what you call the "active form" of B12 and the standard health food store/ pharmacy brand. Aren't they both "active?"
ANSWER: Cyanocobalamin is the most commonly supplemented form of vitamin B12, but you might be surprised to discover that this form of vitamin B12 does not actually occur in plants or animal tissues. In other words, outside of the chemically synthesized cyanocobalamin that you encounter as B12 in most vitamin supplements, you would be extremely hard pressed to find this compound in nature (in fact you would not be able to find it). As the name implies, cyanocobalamin contains a cyanide molecule. Most people are familiar with cyanide as a poisonous substance. Although the amount of cyanide in a normal B12 supplement is small and from a toxicology point, viewed as insignificant, your body will still need to remove and eliminate this compound. This removal is accomplished through your detoxification systems with substances like glutathione being very important for the elimination of the cyanide.
Compared with cyanocobalamin, it appears that methylcobalamin is better absorbed and retained in higher amounts within your tissues. In simple terms, they are used much more effectively. In general, methylcobalamin is used primarily in your liver, brain and nervous system.
Methylcobalamin is the specific form of B12 needed for nervous system health. Because of this it should be the first form of this vitamin thought of when interested in attempting to optimize the health of the nervous system with vitamin supplementation. Indications of a potential deficiency of B12 in the nervous system might include numbness, tingling, loss of feeling sensation, burning sensations, muscle cramps, nerve pain and slowness of reflexes.
Because of methylcobalamin's importance in nervous system health, it is also an important nutrient for vision. In fact, continued visual work (like work on a computer) often leads to a reduction in something called "visual accommodation". Methylcobalamin can significantly improve visual accommodation, while cyanocobalamin appears to be ineffective.
An elevated level of homocysteine is a metabolic indication of decreased levels of the coenzyme forms of vitamin B12, especially methylcobalamin. Homocysteine has received a tremendous amount of emphasis in the scientific literature because of its associations with heart disease and a variety of other specific health conditions. I have even seen advertisements on television promoting folic acid, as a vitamin needed to lower homocysteine. While this is true, and folic acid does lower homocysteine levels, the combination of methylcobalamin and folic acid appears to work much better.
The most well studied use of methylcobalamin has to do with sleep. Although the exact mechanism of action is not yet clear, it is possible that methylcobalamin is needed for the synthesis of melatonin. Available information indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalize circadian rhythm (your 24-hour clock). Because of this, individuals supplementing this form of B12 often have improved quality of sleep, often will require slightly less sleep, and will not uncommonly report that they feel a bit more refreshed when waking in the morning. Methylcobalamin is particularly effective when your 24-hour clock is not running smoothly. This may be indicated by a need for excessive sleep, changing sleep-wake cycles, or a tendency to have altered sleep wake patterns. As examples, you might require 10-12 hours of sleep, or you might not feel tired until 2-3 am and you might wake at noon, or you might find that you wake a bit later every day and go to be a bit later every night. Under all of these circumstances the combination of methylcobalamin (about 3000 mcg daily) and exposure to bright light in the morning can help reestablish your 24-hour clock.
Because of methylcobalamin's impact on 24-hour clock and the cycles that feed of this, it is also an important vitamin to regulate your 24-hour release of the stress hormone cortisol. This seems to be particularly important for blood types A and AB. Methylcobalamin also seems to result in a better 24-hour maintenance of body temperature. Typically individuals supplementing this coenzyme form of B12 have higher temperatures in the later hours of the daytime. This usually corresponds with improved alertness at the same time of the day. While this can be of importance to all blood types, low body temperatures seems to be an area of greater challenge for A's and B's.
Vitamin B12: All Cobalamins are not Equal
From http://www.strokedoctor.com/vitamin_b12.htm
"Vitamin B12: All Cobalamins are not Equal
Look at your multiple vitamin or B complex bottle. You're probably taking cyanocobalamin, the stable and less expensive form of vitamin B12. Because it is stable, it has a longer shelf life. However, the active form of B12 is methylcobalamin and the two are NOT equal in effectiveness. If you have symptoms of GI disorders, lethargy, confusion, slow thought processes, heart rate variability, atherosclerosis, sleep disorders, or immune dysfunction, you may need the methyl as well as the cobalamin component.
The two vitamin B12 coenzymes known to be metabolically active in humans are methylcobalamin and adenosylcobalamin. Vitamin B12 is usually absorbed from the gut from the fermentation of intrinsic factor by intestinal flora. However, production can be disturbed by nutritional deficiencies, intrinsic factor deficiency, bacterial overgrowth, malabsorption, alcohol, and antibiotics. Nitrous oxide anesthesia in surgery and nitric acid from normal metabolism and inflammation also reduce our vitamin B12 levels.
Cobalamins are destroyed by heavy metals and strong oxidizing or reducing agents. (take at different times than vit c). Vitamin B12 deficiency generally increases with age and is common in the elderly.(2)
Both vitamin B12 and folic acid are required for the synthesis of thymidylate, a component of DNA. Lack of adequate DNA synthesis causes many red blood cell precursors (hematopoietic cells) to die in the bone marrow. The development of epithelial cells is also disturbed by thymidylate deficiency. Gut changes due to vitamin B12 deficiency are often related to constipation whereas a folic acid deficiency is generally related to diarrhea. In the brain, the arrest of cell replication due to vitamin B12 deficiency disrupts myelin synthesis, resulting in neural damage in the brain, spinal cord and/or peripheral nerves. Vitamin B12 deficiency can include the following neurological symptoms: numbness and tingling in the hands and feet, unsteadiness, poor muscular coordination, moodiness, mental slowness, poor memory, confusion, agitation, and/or depression.
Vitamin B12 is involved in fat and carbohydrate metabolism. It is required in the synthesis of the amino acid methionine, which is involved in choline and betaine utilization. B12 assists in maintaining sulfhydryl (SH) groups in their reduced form for enzyme activity. Vitamin B12 deficiency is associated with a decrease of reduced glutathione, needed for cell defense against pathogens (viruses, bacteria, fungi) and toxins.
Methylcobalamin is a co-factor of methionine synthase, an enzyme that transfers methyl groups to homocysteine to regenerate methionine. Elevated homocysteine levels are a risk factor for coronary artery disease. (11) Methionine can be transformed to S-adenoxylmethionine (SAM) that is involved in a variety of methylation reactions in the body, one of which is alleviating depression.(13)
Methylcobalamin also plays a role in cell-mediated and humoral immune function in rats. In vitamin B12 deficient rats, serum C3, IgM and Ig G factors were found to be lower. There was also an elevation of the ratio of CD4+ CD8- to DC4- CD8+, which reduces the ability to fight off pathogens.(12)
Cyanocobalamin is not biologically active until converted to methylcobalamin, which also means releasing its cyanide. Cyanide can be toxic because it binds the iron (F3+) portion of cytochrome oxidases, preventing its reduction. This binding blocks electron transport and interrupts cellular respiration. Symptoms of sublethal cyanide toxicity include hypotension, tachypnea, and tachycardia.(4)
Cobalamin can bind with cyanide and is therefore effective in reducing cyanide toxicity. However cyanocobalamin is not effective in removing cyanide because the cobalamin is already bound. (3) Since nitroprusside can induce cyanide toxicity, other cobalamins such as hydroxocobalamin should be used to bind with cyanide. Nitroprusside therapies should be minimized in critically ill patients and those with liver or kidney dysfunction.
Large amounts of cyanocobalamin can exacerbate preexisting cyanide toxicity that can result from smoking tobacco, sodium nitroprusside therapy, and phagocytosis. Steve Roach, M.D. writes that "it seems wise to avoid a potentially harmful form of a drug when the more physiologic variety is available and is excreted at a more desirable rate.(7)
Foods fortified with vitamin B12 (as cyanocobalamin) may be a potential problem if cooked. The highest mutation activity in cooked (pyrolysate) vitamins was found in cyanocobalamin (3220 revertants at .025 mumole of cyanocobalamin).(5)
In a comparison of cobalamins against cancer, adenoxylcobalamin was effective against fast-growing malignant cells. Methylcobalamin was effective at elevated concentrations and cyanocobalamin had no effect in slowing the growth of any of the tumor cell lines studied.(6) In studies that show that vitamin B12 has no effect on cancer growth, we need to look closer at whether cyanocobalamin was used instead of the natural coenzyme forms (adenoxylcobalamin and methylcobalamin).
Methylcobalamin enhances synaptic transmission in learning and memory. Ikeuchi and associates studied the effects of methyl-B12 on the electrical activity in hippocampal neurons and found that methyl-B12 increased post-synaptic field potential which lasted more than an hour and increased the electrical currents elicited by N-methyl-D-aspartate (NMDA). Cyanocobalamin had no effect.(13)
Methylcobalamin plays a role in modulating human circadian rhythms. It accelerates re-entrainment of the activity rhythm to the environmental light-dark cycle. The suprachiasmatic nucleus (SCN) is involved in relaying photic information to the pineal gland. Methylcobalamin enhanced the field potential in the SCN that lasted an hour. In contrast, cyanocobalamin showed no effect.(16)
Methylcobalamin is also required in donating a methyl group for the synthesis of melatonin. Methylcobalamin supplementation can assist in modulating melatonin secretion, enhancing light-sensitivity, normalizing circadian rhythms and improving sleep-wake cycles. (17)
Methylcobalamin also helps improve heart rate variability, suggesting that it is involved in balancing sympathetic and parasympathetic nervous system function,(18) perhaps through its involvement with light entrainment and melatonin synthesis. Since circadian rhythm and melatonin synthesis are key factors in health maintenance, the use of cyanocobalamin rather than methylcobalamin is undermining our health as individuals as well as a nation.
Another study found a correlation between serum vitamin B12 in women and their breast milk. When a group of lactating women were injected with cyanocobalamin, there was also an increase of cyanocobalamin in their breast milk.
As early as 1970, Dr. A.G. Freeman protested against the use of cyanocobalamin in The Lancet. He again wrote a letter in 1978, entitled "Why Has Cyanocobalamin Not Been Withdrawn?" to The Lancet and to the British Committee on Safety of Drugs. Dr. Freeman voiced the concern that even if hydroxocobalamin is prescribed, cyanocobalamin is administered in its place. They wrote that "because doctors are still confused about the differences between various forms of vitamin B12 commercially available and about their possible adverse effects, manufacturers should withdraw cyanocobalamin in favor of hydroxocobalamin for therapeutic use." (8)
A letter from Dr. Terry was published in the October, 1978 issue of The Lancet. He wrote that "the lead for improved prescribing must come form compilers of formularies that are highly regarded. In this respect it is disappointing to find that the W.H.O. expert committee on the selection of essentiald rugs lists only cyanocobalamin, placing an incalculable number of patients with optic neuropathy in pernicious anemia or tobacco and tropical amblyopia at risk." (9)
In the November 1978 issue, the Lancet published a letter by J.C.Linnell and associates entitled "Therapeutic Misuse of Cyanocobalamin." The authors state that cyanocobalamin itself has no known biochemical function. Only trace amounts of cyanocobalmin are normally detectable in the human body, while significant amounts occur in patients with optic neuropathies, inborn errors of cobalamin metabolism and pernicious anemia. Cyanocobalamin must first undergo conversion to the physiological forms of cobalamin before being effective against pernicious anemia. However hydroxocobalamin (a precursor to methyl and andenoxylcobalamin) "has the additional advantage of therapeutic efficacy in certain neuropathies and some cases of inborn errors of cobalamin metabolism." The authors further write that "it is lamentable that an extensive demand for cyanocobalamin as a therapeutic agent should persist. There seems to be no place for the continued therapeutic use of cyanocobalamin." (10)
Vitamin B12 is found in algae, peas, clover, alfalfa, mustard, egg yolk, chedder cheese, sardines, herring, anchovies, calve's liver, haddock, salmon, and cow's milk. Plants containing S-methylmethionine include cabbage, kohlrabi, turnip, tomatoes, celery, leeks, garlic, beets, raspberries and strawberries (14). Cyanocobalamin is in haddock and cassava root. Elevated amounts of cyanocobalamin have been found in smokers and cases of amyotrophic lateral sclerosis and optic atrophy.
Clinical doses of methylcobalamin are 1500-6000 mcg per day and can be administered orally, intramuscularly or intravenously with positive clinical results. Methylcobalamin is well tolerated and has no known toxicity. B complex (riboflavin, folic acid, pyridoxine, and choline), and zinc assist methylcobalamin effectiveness. It is important that physicians giving injections check the source of their vitamin B12. Not only can it be cyano rather than methylcobalamin, but the shot gun approach of giving liver extract can include allergenics. One report states that 10-30% of pharmaceutical preparations may be noncobalamin analogues, that are either inactive or cause allergic reactions. (1)
In conclusion, methylcobalamin can be effective in cases of neuropathy, depression, cancer, optic atrophy, heart rate variability, homocysteinemia, and sleep disturbances. However, all cobalamin analogues are not equal and taking cyanocobalamin with already elevated levels of cyanide can actually be harmful. It has been thirty years since Dr. Freeman first published a letter in The Lancet about the risks of using cyanocobalamin. How much longer can we afford to allow ignorance and profit motives to undermine our nation's health?
REFERENCES:
(1) Herbert, Victor and Neville Colman. "Folic Acid and Vitamin B12" in Shils, Maurice and Vernon R. Young, "Modern Nutrition in Health and Disease." Lea & Febinger, Philadelphia, PA, 1988, pg. 388-416.
(2) Watt, D.T. "Vitamin B12 replacement therapy: how much is enough?" Wisconsin Medical Journal, 1994, 93(5): 203- 5.
(3) Zerbe, N.F. et al. "Use of vitamin B12 in the treatment and prevention of nitroprusside-induced cyanide toxicity." Critical Care Medicine, 1993, 21(3): 465-7.
(4) Williams, H.L. et al. "Studies of cobalamin vehicle for the renal excretion of cyanide anion." Journal of Laboratoyr and Clinical Medicine, 1990, 116(1): 37-44.
(5) Demura, R. et al. "Mutagenic activity of pyrolysate of cyanocobalamin and some other soluble vitamins in the model system with the Salmonella/mammalian microsomes." Mutation Research, 1990, 244(1): 37-42.
(6) Tsao, C.S. et al. "Cytotoxic activity of cobalamin in cultured malignant and nonmalignant cells." Pathobiology, 1990, 58(5): 292-6.
(7) Sawyer, D.R. "Cyanocobalmin and cyanide toxicity (letter)." American Family Physician, 1982, 26(1): 48.50,55.
(8) Freeman, A.G. et al. "Why has cyanocobalamin not been withdrawn?" The Lancet, April 8, 1978; pg. 777-778.
(9) Terry, S.I. et al. "Survival of Cyanocobalmin." The Lancet, October 14, 1978, pg. 848.
(10) Linnell, J.C. et al. "Therapeutic Misuse of Cyanocobalamin". Lancet, November 11, 1978; pg 1053-1054.
(11) Brown, C.A. et al. "A Common Polymorphism in Methionine Synthase Reductase Increases Risk of Premature Coronary Artery Disease." J Cardiovasc Risk 2000, 7(3): 197-200.
(12) Funada, U. et al. "Changes in CD4+ CD8-/CD4- CD8+ ratio and humoral immune functions in vitamin B12-deficient rats." Int J Vitam Nutr Res, 2000, 70(4): 167-71.
(13) Ikeuchi, Youji et al. "Methylcobalamin induces a long-lasting enhancement of the postsynaptic field potential in hippocampal slices of the guinea pig." Neuroscience Leters, 1995, 192: 113-116.
(14) Kovatscheva, E.G. et al. "S-methylmethionine content in plant and animal tissues and stability during storage." Nahrung, 1977, 21(6): 465-72.
(15) Schneider, Z. "Comprehensive B12." Walter de Gruyter, New York, New York, 1987.
(16) Nishikawa, Yukiko et al. "Methylcobalamin induces a long-lasting enhancement of the field potential in rat suprachiasmatic nucleus slices." Neuroscience Letters, 1996: 220: 199-202.
(17) Mayer, G. et al. "Effects of vitamin B12 on performance and circadian rhythm in normal subjects." Neuropsychopharmacology, 1996; 15: 456-464.
(18) Yoshioka, K. et al. "Effect of methylcobalamin on diabetic autonomic neuropathy as assessed by power spectral analysis of heart rate variations." Horm Metab Res, 1995, 27: 43-44"
__________________________________________________
The following supplements contain the Methylated form of B-12 Methylcobalamin:
intraMAX® from Life Enthusiast Co-op
intraKID™
Note: IntraMax & IntraKid now contains both cyanocobalamin AND methylcobalamin. To be on the safe side, take an extra methylcobalamin supplement, like one of the ones below.
Sublingual B-12 (Methylcobalamin)
Tangy Tangerine (Vitamins & colloidal minerals) buy from Youngevity Online
SUBLINGUAL B12 VITAMIN from Bio-Alternatives
INGREDIENTS: Vitamin B12 (Methylcobalamin) in Pure Water
SUPPLEMENT FACTS:
Serving Size - 1/2 dropper (1000 mcg)
Servings per Container - 60
SUGGESTED USE: As a Dietary Supplement 1/2 dropper once or twice daily.
More choices coming soon...
-
Tuesday, July 24, 2012
New Vaccine Added to The Already Witches Brew
One more to the MIX New vaccine called:
MenHibrix that combines two meningitis vaccines into one shot.5,6 The FDA had rejected the license in 2010 and 2011 because, reportedly, the British drug company giant was having trouble proving the vaccine actually worked. 7
But it has now been approved.
http://articles.mercola.com/sites/articles/archive/2012/07/24/new-vaccines-for-babies.aspx?e_cid=20120724_DNL_artNew_2
MenHibrix - Package insert
http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf
Please read the package insert, read contraindications and ESPECIALLY ADVERSE REACTIONS.
Then read it again, because y'all aren't getting it. Vaccines have never worked except to spread disease and death. They KILL and MAIM. Always have and always will.
Folks, are you getting it yet? Or do I have to post a bazillion more posts?
MenHibrix that combines two meningitis vaccines into one shot.5,6 The FDA had rejected the license in 2010 and 2011 because, reportedly, the British drug company giant was having trouble proving the vaccine actually worked. 7
But it has now been approved.
http://articles.mercola.com/sites/articles/archive/2012/07/24/new-vaccines-for-babies.aspx?e_cid=20120724_DNL_artNew_2
MenHibrix - Package insert
http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf
Please read the package insert, read contraindications and ESPECIALLY ADVERSE REACTIONS.
Then read it again, because y'all aren't getting it. Vaccines have never worked except to spread disease and death. They KILL and MAIM. Always have and always will.
Folks, are you getting it yet? Or do I have to post a bazillion more posts?
A Great Fan
Well, since the site doesn't have an order link or price, I found it on Amazon. ACE Hardware stores should have it too.
Seabreeze 3200-0 Turbo-Aire
No, no, not another reader finding my articles fabulous.
I'm referring to a great HOUSE FAN. I bought it cheap for $70 from Ace Hardware last year. Ordered it special.
This is the product page:
http://www.seabreeze.ca/fans/TurboAire/turboaire.htm
Patented from Canada by aeronautical engineers. Except for David and Barney, the only good thing that comes from that country.
This fan feels like you're in a wind tunnel. Check out the specs on the volume of air it moves.
It's quiet too. And it's low energy consumption.
This is a life saver if you dont have AC.
Just two pieces of advice:
1. there are easy to clean plastic shields front and back. clean it when hair and dirt builds up on it. because that will greatly reduce it's effectiveness.
2. The fan pushes out so much air, that if you place it on a smooth table, it will move backward sliding on the table (it even looks like a plane engine).
Solution is to pick up some rubber hosing at a auto parts store or plumbing/hardware. about 16 inches long and about 1 inch inner diameter.
then slit it down the middle so you can clamp it onto the two metal cylinders that the fan rests on (if you lay it on a table). acts like rubber feet.
gary
Subscribe to:
Posts (Atom)